So far the one thing I have found that seems to have the least side effects and sedation has been Zofran...however, I'm hesitant to ask my doctor about this since wikipedia describes it as an anti-nausea drug for those undergoing chemotherapy for cancer so I dont know how often it would be prescribed to someone experiencing nausea/vomiting for other reasons. Nausea and vomiting are mediated primarily by visceral stimulation through dopamine and serotonin, by vestibular and central nervous system causes through histamine and acetylcholine, and by chemoreceptor trigger zone stimulation through dopamine and serotonin. Antihistamines and anticholinergic agents are most effective in patients with nausea resulting from vestibular and central nervous system causes.According to Soto et al (2013), hair cells and efferent neurons release numerous other neuroactive substances including CGRP, substance-P, opiod peptides, endocannabinoids, GABA, ATP, nitrous oxide, adenosine and histamine.Acetylcholine (ACH) is both a peripheral and central agonist affecting muscarinic receptors, including the vestibular nucleus as well as efferent synapses (Soto et al, 2013).
Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.
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When the exact cause is not known or cannot be corrected, symptoms still can be treated.
Three primary pathophysiologic pathways are involved in the stimulation of the physiologic vomiting center in the medulla that directly mediates nausea and vomiting.3 This center can be stimulated by vestibular fibers, afferent visceral fibers, and input from the chemoreceptor trigger zone in the base of the fourth ventricle4 receptor, and anticholinergic agents inhibit the action of acetylcholine at the muscarinic receptor.